A cohort of balanced reciprocal translocations associated with dyslexia: identification of two putative candidate genes at DYX1

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A cohort of balanced reciprocal translocations associated with dyslexia: identification of two putative candidate genes at DYX1. / Buonincontri, Roberta; Bache, Iben; Silahtaroglu, Asli; Elbro, Carsten; Nielsen, Anne-Mette Veber; Ullmann, Reinhard; Arkesteijn, Ger; Tommerup, Niels.

I: Behavior Genetics, Bind 41, Nr. 1, 01.01.2011, s. 125-33.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Buonincontri, R, Bache, I, Silahtaroglu, A, Elbro, C, Nielsen, A-MV, Ullmann, R, Arkesteijn, G & Tommerup, N 2011, 'A cohort of balanced reciprocal translocations associated with dyslexia: identification of two putative candidate genes at DYX1', Behavior Genetics, bind 41, nr. 1, s. 125-33. https://doi.org/10.1007/s10519-010-9389-2

APA

Buonincontri, R., Bache, I., Silahtaroglu, A., Elbro, C., Nielsen, A-M. V., Ullmann, R., Arkesteijn, G., & Tommerup, N. (2011). A cohort of balanced reciprocal translocations associated with dyslexia: identification of two putative candidate genes at DYX1. Behavior Genetics, 41(1), 125-33. https://doi.org/10.1007/s10519-010-9389-2

Vancouver

Buonincontri R, Bache I, Silahtaroglu A, Elbro C, Nielsen A-MV, Ullmann R o.a. A cohort of balanced reciprocal translocations associated with dyslexia: identification of two putative candidate genes at DYX1. Behavior Genetics. 2011 jan. 1;41(1):125-33. https://doi.org/10.1007/s10519-010-9389-2

Author

Buonincontri, Roberta ; Bache, Iben ; Silahtaroglu, Asli ; Elbro, Carsten ; Nielsen, Anne-Mette Veber ; Ullmann, Reinhard ; Arkesteijn, Ger ; Tommerup, Niels. / A cohort of balanced reciprocal translocations associated with dyslexia: identification of two putative candidate genes at DYX1. I: Behavior Genetics. 2011 ; Bind 41, Nr. 1. s. 125-33.

Bibtex

@article{bb758d7f0aa34cd38dfc3d0a1e9335c2,
title = "A cohort of balanced reciprocal translocations associated with dyslexia: identification of two putative candidate genes at DYX1",
abstract = "Dyslexia is one of the most common neurodevelopmental disorders where likely many genes are involved in the pathogenesis. So far six candidate dyslexia genes have been proposed, and two of these were identified by rare chromosomal translocations in affected individuals. By systematic re-examination of all translocation carriers in Denmark, we have identified 16 different translocations associated with dyslexia. In four families, where the translocation co-segregated with the phenotype, one of the breakpoints concurred (at the cytogenetic level) with either a known dyslexia linkage region--at 15q21 (DYX1), 2p13 (DYX3) and 1p36 (DYX8)--or an unpublished linkage region at 19q13. As a first exploitation of this unique cohort, we identify three novel candidate dyslexia genes, ZNF280D and TCF12 at 15q21, and PDE7B at 6q23.3, by molecular mapping of the familial translocation with the 15q21 breakpoint.",
author = "Roberta Buonincontri and Iben Bache and Asli Silahtaroglu and Carsten Elbro and Nielsen, {Anne-Mette Veber} and Reinhard Ullmann and Ger Arkesteijn and Niels Tommerup",
year = "2011",
month = jan,
day = "1",
doi = "10.1007/s10519-010-9389-2",
language = "English",
volume = "41",
pages = "125--33",
journal = "Behavior Genetics",
issn = "0001-8244",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - A cohort of balanced reciprocal translocations associated with dyslexia: identification of two putative candidate genes at DYX1

AU - Buonincontri, Roberta

AU - Bache, Iben

AU - Silahtaroglu, Asli

AU - Elbro, Carsten

AU - Nielsen, Anne-Mette Veber

AU - Ullmann, Reinhard

AU - Arkesteijn, Ger

AU - Tommerup, Niels

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Dyslexia is one of the most common neurodevelopmental disorders where likely many genes are involved in the pathogenesis. So far six candidate dyslexia genes have been proposed, and two of these were identified by rare chromosomal translocations in affected individuals. By systematic re-examination of all translocation carriers in Denmark, we have identified 16 different translocations associated with dyslexia. In four families, where the translocation co-segregated with the phenotype, one of the breakpoints concurred (at the cytogenetic level) with either a known dyslexia linkage region--at 15q21 (DYX1), 2p13 (DYX3) and 1p36 (DYX8)--or an unpublished linkage region at 19q13. As a first exploitation of this unique cohort, we identify three novel candidate dyslexia genes, ZNF280D and TCF12 at 15q21, and PDE7B at 6q23.3, by molecular mapping of the familial translocation with the 15q21 breakpoint.

AB - Dyslexia is one of the most common neurodevelopmental disorders where likely many genes are involved in the pathogenesis. So far six candidate dyslexia genes have been proposed, and two of these were identified by rare chromosomal translocations in affected individuals. By systematic re-examination of all translocation carriers in Denmark, we have identified 16 different translocations associated with dyslexia. In four families, where the translocation co-segregated with the phenotype, one of the breakpoints concurred (at the cytogenetic level) with either a known dyslexia linkage region--at 15q21 (DYX1), 2p13 (DYX3) and 1p36 (DYX8)--or an unpublished linkage region at 19q13. As a first exploitation of this unique cohort, we identify three novel candidate dyslexia genes, ZNF280D and TCF12 at 15q21, and PDE7B at 6q23.3, by molecular mapping of the familial translocation with the 15q21 breakpoint.

U2 - 10.1007/s10519-010-9389-2

DO - 10.1007/s10519-010-9389-2

M3 - Journal article

C2 - 20798984

VL - 41

SP - 125

EP - 133

JO - Behavior Genetics

JF - Behavior Genetics

SN - 0001-8244

IS - 1

ER -

ID: 33495889